Molecular Targets In Protein Misfolding And Neurodegenerative Disease


Molecular Targets In Protein Misfolding And Neurodegenerative Disease
Author: Pierfausto Seneci
Publisher: Academic Press
ISBN: 0128004991
Size: 21.90 MB
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Molecular Targets In Protein Misfolding And Neurodegenerative Disease

Molecular Targets In Protein Misfolding And Neurodegenerative Disease by Pierfausto Seneci, Molecular Targets In Protein Misfolding And Neurodegenerative Disease Books available in PDF, EPUB, Mobi Format. Download Molecular Targets In Protein Misfolding And Neurodegenerative Disease books, Aimed at "drug discoverers" – i.e. any scientist who is interested in neurodegenerative diseases in general, and in finding disease-modifying treatments in particular – the first edition of Molecular Targets in Protein Misfolding and Neurodegenerative Disease will contain both a detailed, discipline-specific coverage (paragraphs on medicinal chemistry, on clinical and preclinical characterization of compounds in development, on target identification and validation, on genetic factors influencing a pathology, etc.) and a drug discovery-oriented, overall evaluation of each target (validation, druggability, existing leads, etc.). Together these will satisfy the needs of various audiences, including in vitro biologists, pharmacologists, medicinal chemists, etc. Written to provide a comprehensive coverage of disease-modifying mechanisms and compounds against neurodegenerative diseases Provides a “drug discovery application oriented perspective, evaluating targets and candidates for their overall therapeutic potential Provides discipline-specific chapters (medicinal chemistry, target validation, preclinical and clinical development Provides an overview on a number of molecular mechanisms (e.g. phosphorylation, chaperon refolding, ubiquitination, autophagy, microtubule transportation, protease cleavage, etc.) with relevance for any disease area Contains a more thorough description of the therapeutic relevance of ~10 specific molecular targets


Molecular Targets in Protein Misfolding and Neurodegenerative Disease
Language: en
Pages: 314
Authors: Pierfausto Seneci
Categories: Science
Type: BOOK - Published: 2014-10-07 - Publisher: Academic Press
Aimed at "drug discoverers" – i.e. any scientist who is interested in neurodegenerative diseases in general, and in finding disease-modifying treatments in particular – the first edition of Molecular Targets in Protein Misfolding and Neurodegenerative Disease will contain both a detailed, discipline-specific coverage (paragraphs on medicinal chemistry, on clinical and
Protein Misfolding
Language: en
Pages: 450
Authors: Rossen Donev
Categories: Science
Type: BOOK - Published: 2020-01-17 - Publisher: Academic Press
Protein Misfolding, Volume 118, covers the wide spectrum of diseases and disorders that are attributed to protein misfolding, including degenerative and neurodegenerative, cardiovascular, renal, glaucoma, cancer, cystic fibrosis, Gaucher's disease, and many others. Specific chapters cover Mass spectrometric approaches for profiling protein folding and stability, Biomembranes, a key player in
Departments of Labor, Health and Human Services, Education, and Related Agencies Appropriations for 2013
Language: en
Pages:
Authors: United States. Congress. House. Committee on Appropriations. Subcommittee on the Departments of Labor, Health and Human Services, Education, and Related Agencies
Categories: Administrative agencies
Type: BOOK - Published: 2012 - Publisher:
Books about Departments of Labor, Health and Human Services, Education, and Related Agencies Appropriations for 2013
Epidemiology of Chronic Disease: Global Perspectives
Language: en
Pages: 800
Authors: Randall E. Harris
Categories: Social Science
Type: BOOK - Published: 2019-04-15 - Publisher: Jones & Bartlett Learning
Epidemiology of Chronic Disease: Global Perspectives is the most current and authoritative resource on the epidemiology, etiology, pathogenesis, risk factors and preventive factors of over 50 major chronic diseases and conditions. This comprehensive text provides readers with an excellent basis for examining current hypotheses regarding chronic disease epidemiology.
The Oxford Handbook of Adult Cognitive Disorders
Language: en
Pages: 944
Authors: Michael L. Alosco, Robert A. Stern
Categories: Medical
Type: BOOK - Published: 2019-06-03 - Publisher: Oxford Library of Psychology
The prevalence of adult cognitive disorders will dramatically rise over the next 25 years due to the aging population. Clinical research on adult cognitive disorders has rapidly evolved, including evidence of new adult cognitive disorders and greater insight into the clinical presentation, mechanism, diagnosis, and treatment of established diseases. The
Alzheimer's Disease
Language: en
Pages: 298
Authors: Renee D. Wegrzyn, Alan S. Rudolph
Categories: Medical
Type: BOOK - Published: 2012-04-26 - Publisher: CRC Press
In recent years, a tremendous amount of effort has been focused on better understanding the fundamentals of Alzheimer’s disease (AD) to facilitate early and accurate diagnosis and appropriately targeted therapeutic treatments. Alzheimer’s Disease: Targets for New Clinical, Diagnostic, and Therapeutic Strategies provides a detailed synopsis of the current state of
Protein Misfolding in Neurodegenerative Diseases
Language: en
Pages: 592
Authors: Robert D. E. Sewell
Categories: Science
Type: BOOK - Published: 2007-12-03 - Publisher: CRC Press
Research focused on protein folding, misfolding, and aggregation is leading to major advances across biochemistry and medicine. The elucidation of a folding code is proving to be of extreme importance in the postgenomic era, where a number of orphan genes have been identified for which no clear function has yet
Protein Quality Control in Neurodegenerative Diseases
Language: en
Pages: 136
Authors: Richard I. Morimoto, Yves Christen
Categories: Medical
Type: BOOK - Published: 2012-12-13 - Publisher: Springer Science & Business Media
The health of the proteome depends upon protein quality control to regulate the proper synthesis, folding, translocation, and clearance of proteins. The cell is challenged constantly by environmental and physiological stress, aging, and the chronic expressions of disease associated misfolded proteins. Substantial evidence supports the hypothesis that the expression of
Heat Shock Proteins and the Brain: Implications for Neurodegenerative Diseases and Neuroprotection
Language: en
Pages: 373
Authors: Alexzander A.A. Asea, Ian R. Brown
Categories: Medical
Type: BOOK - Published: 2008-04-06 - Publisher: Springer Science & Business Media
With the prevalence of neurodegenerative diseases on the rise as average life expectancy increases, the hunt for effective treatments and preventive measures for these disorders is a pressing challenge. Neurodegenerative disorders such as Alzheimer’s disease, Huntington’s disease, Parkinson’s disease and amyotrophic lateral sclerosis have been termed ‘protein misfolding disorders’ that
The Role of Hsp90 in Viral Replication
Language: en
Pages: 304
Authors: Ron Geller
Categories: Medical
Type: BOOK - Published: 2008 - Publisher:
Books about The Role of Hsp90 in Viral Replication